[ The Soviet scientist E.N. Sokolov, who has put forward the most comprehensive explanation of how the orentation response (OR) works, suggests that neural cells in the brain store information about the intensity, duration, quality, and sequence of incoming stimuli. When new stimuli arrive, these are matched against the 'neural models' in the cortex. If the stimuli are novel, they don not match any existing neural model, and the OR takes place. If, however, the matching process reveals their similarity to previously stored models, the cortex shoots signals to the reticular activating system, instructing it, in effect, to hold its fire. ]
While novelty in the environment raises or lowers the rate at which ORs occur, some novel conditions call forth even more powerful responses. We are driving along a monotonous turn-pike, listening to the radio and beginning to daydream. Suddenly, a car speeds by, forcing us to swerve out of our lane. We react automatically, almost instantaneously, and the OR is very pronounced. We can feel our heart pumping and our hands shaking. It takes a while before the tension subsides.
But what if it does not subside? What happens when we are placed in a situation that demands a complex set of physical and psychological reactions and in which the pressure is sustained? What happens if, for example, the boss breathes hotly down our collar day after day? What happens when one of our children is seriously ill? Or when, on the other hand, we look forward eagerly to a 'big date' or to closing an important business deal?
Such situations cannot be handled by the quick spurt of energy provided by the OR, and for these we have what might be termed the 'adaptive reaction'. This is closely related to the OR. Indeed, the two processes are so intertwined that the OR can be regarded as part of, or the initial phase of, the larger, more encompassing adaptive reaction. But while the OR is primarily based on the nervous system, the adaptive reaction is heavily dependent upon the endocrine glands and the hormones they shoot into the blood-stream. The first line of defence is neural; the second is hormonal.
When individuals are forced to make repeated adaptations to novelty, and especially when they are compelled to adapt to certain situations involving conflict and uncertainty, a pea-sized gland called the pituitary pumps out a number of substances. One of these, ACTH, goes to the adrenals. This causes them, in turn, to manufacture certain chemicals termed corticosteroids. When these are released, they speed up body metabolism. They raise blood pressure. They send anti-inflammatory substances through the blood to fight infection at wound sites, if any. And they begin turning fat and protein into dispersible energy, thus tapping into the body's reserve tank of energy. The adaptive reaction provides a much more potent and sustained flush of energy than the OR.
Like the orientation response, the adaptive reaction is no rarity. It takes longer to arouse and it lasts longer, but it happens countless times even within the course of a single day, responding to changes in our physical and social environment. The adaptive reaction, sometimes known by the more dramatic term 'stress', can be touched off by shifts and changes in the psychological climate around us. Worry, upset, conflict, uncertainty, even happy anticipation, hilarity and joy, all set the ACTH factory working. The very anticipation of change can trigger the adaptive reaction. The need to alter one's way of life, to trade an old job for a new one, social pressures, status shifts, life-style modifications, in fact, anything that forces us to confront the unknown, can switch on the adaptive reaction.
Dr Lennart Levi, director of the Clinical Stress Laboratory at the Karolinska Hospital in Stockholm, has shown, for example, that even quite small changes in the emotional climate or in inter-personal relationships can produce marked changes in body chemistry. Stress is frequently measured by the amount of corticosteroids and catecholamines (adrenaline and nor-adrenalin, for example) found in the blood and urine. In one series of experiments Levi used films to generate emotions and plotted the resultant chemical changes.
A group of Swedish male medical students were shown film clips depicting murders, fights, torture, execution and cruelty to animals. The adrenalin component of their urine rose an average 70 per cent as measured before and after. Nor-adrenalin rose an average 35 per cent. Next a group of young female office workers were shown four different films on successive nights. The first was a bland travelougue. They reported feelings of calmness and equanimity, and their output of catecholamines fell. The second night they watched Stanley Kubrick's Paths of Glory and reported feeling intense excitement and anger. Adrenalin output shot upwards. The third night they viewed Charley's Aunt, and roared with laughter at the comedy. Despite the pleasant feelings and the absence of any scenes of aggression or violence, their catecholamines rose signficantly again. The fourth night they saw The Devil's Mask, a thriller during which they actually screamed with fright. Not unexpectedly, catecholamine output soared. In short, emotional response, almost without regard for its character, is accomplished by (or, indeed, reflects) adrenal activity.
Similar findings have been demonstrated again and again in the case of men and women - not to speak of rats, dogs, deer and other experimental animals - involved in 'real' as distinct from 'vicarious' experiences. Sailors in underwater demolition training, men stationed in lonely outposts in Antarctica, astronauts, factory workers, executives have all shown similar chemical responsiveness to change in the external environment.
The implications of this have hardly begun to register, yet there is increasing evidence that repeated stimulation of the adaptive reaction can be seriously damaging, that excessive activation of the endocrine system leads to irreversible 'wear and tear'. Thus, we are warned by Dr Rene Dubos, author of Man Adapting, that such changeful circumstances as 'competitive situations, operation within a crowded environment, change in a very profound manner the secretion of hormones. One can type-read that in the blood or the urine. Just a mere contact with the complex human situation almost automatically brings this about, the stimulation of the whole endocrine system.'
What of it?
'There is,' Dubos declares, 'absolutely no question that one can overshoot the stimulation of the endocrine system and that this has physiological consequences that last throughout the whole lifetime of the organs.'
Years ago, Dr Hans Selye, a pioneer investigator of the body's adaptive responses, reported that 'animals in which intense and prolonged stress is produced by any means suffer from sexual derangements . . . Clinical studies have confirmed the fact that people exposed to stress react very much like experimental animals in all these respects. In women the monthly cycles become irregular or stop altogether, and during lactation milk secretion may become insufficient for the baby. In men both the sexual urge and sperm-cell formation are diminished.'
Since then population experts and ecologists have compiled impressive evidence that heavily stressed populations of rats, deer - and people - show lower fertility levels than less stressed control groups. Crowding, for example, a condition that involves a constant high level of interpersonal interaction and compels the individual to make extremely frequent adaptive reactions has been shown, at least in animals, to enlarge the adrenals and cause a noticeable drop in fertility.
The repeated firing of the OR and the adaptive reaction, by overloading the neural and endocrine systems, is linked to other diseases and physical problems as well. Rapid change in the environment makes repeated calls on the energy supply of the body. This leads to a speed-up of fat metabolism.
...
Source:
Alvin Toffler, Future Shock: (London, S.W., Pan Books Ltd., 1971), 307-310.